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Inhibition of Pyridine Nucleotide Transhydro-genase by Dicumarol

Nature volume 200, pages 71–72 (1963)Cite this article

Abstract

WE have recently described the hormonal sensitivity of a transhydrogenase reaction in mitochondria (reaction I)1. Reaction I is stimulated by diethylstilbœstrol and œstradiol and thus differs from the transhydrogenase of Kaplan2. This may reflect a difference in the method of preparation which preserves its hormonal sensitivity3. In further studies of this reaction, the reverse direction (reaction II) has been examined. In this report, the inhibitory effect of dicumarol on reactions I and II will be described.

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Author information

Authors and Affiliations

  1. Section of Dermatology, Department of Medicine, Yale University School of Medicine, New Haven, Conn.

    JOSEPH MCGUIRE

  2. Rutgers Medical School, Rutgers, the State University, New Brunswick, New Jersey

    LEROY PESCH

  3. Yale University School of Medicine, New Haven, Conn.

    HELEN FANNING

Authors
  1. JOSEPH MCGUIRE
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  2. LEROY PESCH
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  3. HELEN FANNING
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MCGUIRE, J., PESCH, L. & FANNING, H. Inhibition of Pyridine Nucleotide Transhydro-genase by Dicumarol. Nature 200, 71–72 (1963). https://doi.org/10.1038/200071a0

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  • DOI: https://doi.org/10.1038/200071a0

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