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Evidence of the Mechanism of Ouabain Inhibition of Cation Activated Adenosine Triphosphatase

Abstract

OUABAIN has been shown to inhibit electrolyte transport in a number of tissues, including erythrocytes1,2, brain and kidney3,4. Ouabain also inhibits that adenosine triphosphatase obtained from membrane and sub-cellular preparations which is stimulated by sodium plus potassium ions5–7. Recent work has shown that this enzyme must play an important part in the mechanism of active ion transport7–10.

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References

  1. Schatzmann, H. J., Helv. physiol. Acta, 11, 346 (1953).

    CAS  Google Scholar 

  2. Kahn, J. B., and Acheson, G. H., J. Pharmacol., 115, 305 (1955).

    CAS  Google Scholar 

  3. Yoshida, H., Nakada, T., and Fujisawa, H., Biochim. Biophys. Acta, 48, 614 (1961).

    Article  CAS  Google Scholar 

  4. Whittam, R., and Wheeler, K. P., Biochim. Biophys. Acta, 51, 622 (1961).

    Article  CAS  Google Scholar 

  5. Dunham, E. T., and Glynn, I. M., J. Physiol., 156, 274 (1961).

    Article  CAS  Google Scholar 

  6. Post, R. L., Merritt, C. R., Kinsolving, C. R., and Albright, C. D., J. Biol. Chem., 235, 1796 (1960).

    CAS  Google Scholar 

  7. Wheeler, K. P., and Whittam, R., Biochem. J., 85, 495 (1962).

    Article  CAS  Google Scholar 

  8. Skou, J. C., Biochim. Biophys. Acta, 58, 314 (1962).

    Article  CAS  Google Scholar 

  9. Aldridge, W. N., Biochem. J., 83, 527 (1962).

    Article  CAS  Google Scholar 

  10. Bonting, S. L., Caravaggio, L. L., and Hawkins, N. M., Arch. Biochem. Biophys., 98, 413 (1962).

    Article  CAS  Google Scholar 

  11. Charnock, J. S., and Post, R. L., Austral. J. Exp. Biol. and Med. Sci. (in the press).

  12. Schwartz, A., Bachelard, H. S., and McIlwain, H., Biochem. J., 84, 626 (1962).

    Article  CAS  Google Scholar 

  13. Charnock, J. S., Rosenthal, A. L., and Post, R. L., Fed. Proc., 22, 212 (1963).

    Google Scholar 

  14. Whittam, R., Biochem. J., 84, 110 (1962).

    Article  CAS  Google Scholar 

  15. Post, R. L., and Albright, C. D., Symp. Membrane Transport and Metabolism, Prague, 1961, edit. by Kleinzeller, A., and Kotyk, A., 219 (Publishing House, Czechoslovak Acad. Sci.).

    Google Scholar 

  16. Järnefelt, J., Biochem. Biophys. Res. Comm., 6, 285 (1961).

    Article  Google Scholar 

  17. Hokin, L. E., and Hokin, M. R., J. Gen. Physiol., 44, 61 (1960).

    Article  CAS  Google Scholar 

  18. Kanfer, J., and Titmus, E., Biochim. Biophys. Acta, 54, 601 (1961).

    Article  CAS  Google Scholar 

  19. Heard, P. J., Nature, 193, 451 (1962).

    Article  ADS  Google Scholar 

  20. Judah, J. D., and Ahmed, K., Biochim. Biophys. Acta, 71, 34 (1963).

    Article  CAS  Google Scholar 

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CHARNOCK, J., POST, R. Evidence of the Mechanism of Ouabain Inhibition of Cation Activated Adenosine Triphosphatase. Nature 199, 910–911 (1963). https://doi.org/10.1038/199910a0

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