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Evidence of the Mechanism of Ouabain Inhibition of Cation Activated Adenosine Triphosphatase

Naturevolume 199pages910911 (1963) | Download Citation

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Abstract

OUABAIN has been shown to inhibit electrolyte transport in a number of tissues, including erythrocytes1,2, brain and kidney3,4. Ouabain also inhibits that adenosine triphosphatase obtained from membrane and sub-cellular preparations which is stimulated by sodium plus potassium ions5–7. Recent work has shown that this enzyme must play an important part in the mechanism of active ion transport7–10.

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Author information

Author notes

    • J. S. CHARNOCK

    Present address: Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia

Affiliations

  1. Department of Physiology, Vanderbilt University Medical School, Nashville, Tenn.

    • J. S. CHARNOCK
    •  & R. L. POST

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https://doi.org/10.1038/199910a0

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