Letter | Published:

Formation of Histamine in Ruminal Fluid

Naturevolume 199pages829830 (1963) | Download Citation



HISTIDINE and other amino-acids normally undergo deamination in ruminal fluid1, and decarboxylation with the formation of histamine does not normally occur in the rumen to any great extent. When sheep or cattle are fed a diet containing excessive amounts of carbohydrate, however, the histamine content of ruminal fluid may increase considerably and concentrations > 70 µg/ml. have been recorded2. Van der Horst3 has shown that the concentration of amino-acids and amines in ruminal fluid can be increased by incubation with glucose.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Lewis, D., Brit. J. Nutr., 9, 215 (1955).

  2. 2

    Dain, J. A., Neal, A. L., and Dougherty, R. W., J. Anim. Sci., 14, 930 (1955).

  3. 3

    Van der Horst, C. J. G., Nature, 191, 73 (1961).

  4. 4

    Blaschko, H., Ciba Found. Symp. Histamine, 202 (Churchill, London, 1956).

  5. 5

    Broberg, G., Acute Overeating with Cereals in Ruminants (A. B. Lavisa Nya Tryckeri, Lavisa, Finland, 1960).

Download references

Author information


  1. University of Glasgow Veterinary Hospital, Bearsden, Glasgow

    • J. SANFORD


  1. Search for J. SANFORD in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.