Abstract
Taranta, Weiss and Franklin1 and Müller-Eberhard and Kunkel2 independently described a heat-labile substance in normal human serum which was capable of precipitating soluble aggregates of γ-globulin. The latter authors2 isolated the factor from aggregated γ-globulin precipitated with normal human serum in the presence of ethylenediamine tetraacetic acid (EDTA). They showed that it was a euglobulin with an S020w of 11 and further demonstrated that it constituted a component of hæmolytic complement distinct from the known components of the human system. They termed it the “11 S component”. It will be shown that this same component is also present in guinea pig and rabbit serum and that it can be removed from these sera with immune precipitates in the presence of EDTA.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Taranta, A., Weiss, H. S., and Franklin, E. C., Nature, 189, 239 (1961).
Müller-Eberhard, H. J., and Kunkel, H. G., Proc. Soc. Exp. Biol. Med., 106, 291 (1961).
Kent, J. F., Bukantz, S. C., and Rein, C. R., J. Immunol., 53, 37 (1946).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BARBARO, J. Demonstration of a Hæmolytically Active II S Component of Rabbit, Guinea Pig and Human Serum by means of Antigen–Antibody Precipitates. Nature 199, 819–820 (1963). https://doi.org/10.1038/199819a0
Issue Date:
DOI: https://doi.org/10.1038/199819a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.