Letter | Published:

Pharmacological Characteristics of Neuro-hypophysial Hormones in Lungfish and Amphibians

Naturevolume 199pages611612 (1963) | Download Citation



THE morphologicol similarity between the neurohypophysis of lungfishes and amphibians1 suggested a comparison of the neurohypophysial hormones of these groups of vertebrates. When extracts of the neural lobe of Protopterus aethiopicus Owen were chromatographed and pharmacologically characterized, we2 found that they contained one active principle (8-arginine oxytocin, vasotocin) common to both teleosts and amphibians. The other oxytocic peptide found differed pharmacologically from the second hormone in teleost glands, that is, from ichthyotocin3, which has now been identified as 4-serine 8-isoleucine oxytocin4,5.

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  1. 1

    Wingstrand, K. G., Vidensk. Medd. Dansk naturh. Foren., 118, 193 (1956).

  2. 2

    Follett, B. K., and Heller, H., Gen. Comp. Endocrinol., 2, 606 (1962).

  3. 3

    Heller, H., Pickering, B. T., Maetz, J., and Morel, F., Nature, 191, 670 (1961).

  4. 4

    Acher, R., Chauvet, J., Chauvet, M. T., and Crepy, D., Biochim. Biophys. Acta, 58, 624 (1962).

  5. 5

    Follett, B. K., and Heller, H., Proc. Second Intern. Pharmacol. Meeting, Prague (in preparation).

  6. 6

    Sawyer, W. H., Munsick, R. A., and van Dyke, H. B., Endocrinol., 68, 215 (1961).

  7. 7

    Berde, B., and Konzett, H., Medicina Exp., 2, 317 (1960); cited from Boissonnas, R. A., Guttmann, St., Berde, B., and Konzett, H., Experientia, 17, 377 (1961).

  8. 8

    Follett, B. K., and Heller, H. (unpublished observations).

  9. 9

    Morel, F., Maetz, J., Acher, R., Chauvet, J., and Lenci, M. T., Nature, 190, 828 (1961).

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  1. Department of Pharmacology, University of Bristol

    • B. K. FOLLETT
    •  & H. HELLER


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