Letter | Published:

Biological Activity of a Brownish-Yellow Pigment produced from Vitamin B12 by Aerobacter aerogenes

Naturevolume 199pages604605 (1963) | Download Citation



IT has previously1 been shown that two brownish-yellow pigments could be isolated from the incubation mixture when a strain of Aerobacter aerogenes is grown in the presence of vitamin B12 in a glucose-salt medium. The pigment (pigment I) present in greatest quantity was shown to be derived from vitamin B12. It differed from vitamin B12 in its absorption spectrum and its electrophoretic and chromatographic properties. It was stable to air and light and was not as the cobamide coenzymes converted to aquocobalamin by the addition of potassium cyanide.

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  1. 1

    Helegeland, K., Jonsen, J., and Laland, S., Biochem. J., 81, 260 (1961).

  2. 2

    Ford, J. E., Brit. J. Nutrit., 7, 299 (1953).

  3. 3

    Killander, A., Acta Chem. Scand., 9, 1045 (1955).

  4. 4

    Ungley, C. C., Vitamins and Hormones, 13, 173 (1955).

  5. 5

    Coates, M. E., and Kon, S. K., Vitamin B12 and Intrinsic Factor, 72 (Ferdinand Enke Verlag, Stuttgart, 1957). Blumberger, K., Petrides, P., and Bernhauer, K., ibid., 82.

  6. 6

    Hill, J. A., Pratt, J. M., and Williams, R. J. P., J. Theor. Biol., 3, 423 (1962).

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  1. Department of Biochemistry, University of Oslo, Blindern

    • , J. JONSEN
    • , S. LALAND
    • , T. LYGREN
    •  & O. RØMCKE
  2. Drammen Hospital, Drammen, Norway

    • , J. JONSEN
    • , S. LALAND
    • , T. LYGREN
    •  & O. RØMCKE


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