Letter | Published:

Stimulation by Rat Liver Ribonucleic Acid of Incorporation of Amino-acid into Rat Liver Ribosomes

Naturevolume 199pages489490 (1963) | Download Citation

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Abstract

THE discovery1 that ribonucleic acid (RNA) and synthetic polyribonucleotides stimulated the incorporation of amino -acids into protein-like material in cell-free system from E. coli has been followed by many reports2–6 of similar findings with systems from the same and other cells. Rat liver RNA was shown5 to stimulate amino-acid incorporation when added to an E. coli system and rat liver RNA and polyuridylic acid caused increased incorporation of phenylalanine in a rat-liver microsomal system6. We wish to report that polyuridylic acid and rat liver RNA stimulate incorporation of amino-acid with rat liver ribo-somes.

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References

  1. 1

    Nirenberg, M. W., and Matthaei, J. H., Proc. U.S. Nat. Acad. Sci., 47, 1588 (1961).

  2. 2

    Lengyel, P., Speyer, J. F., and Ochoa, S., Proc. U.S. Nat. Acad. Sci., 47, 1936 (1961).

  3. 3

    Arnstein, H. R. V., Cox, R. A., and Hunt, J. A., Biochem. J., 84, 918 (1962).

  4. 4

    Ofengand, J., and Hazelkorn, R., Biochem. Biophys. Res. Comm., 6, 469 (1961).

  5. 5

    Barondes, S. H., Dingman, C. W., and Sporn, M. B., Nature, 196, 145 (1962).

  6. 6

    Maxwell, E. S., Proc. U.S. Nat. Acad. Sci., 48, 1639 (1962).

  7. 7

    Hall, B. D., and Doty, P., J. Mol. Biol., 1, 111 (1959).

  8. 8

    Brown Hill, T. J., Jones, A. S., and Stacey, M., Biochem. J., 73, 434 (1959).

  9. 9

    Korner, A., Biochem. J., 81, 168 (1961).

  10. 10

    Elson, D., Biochim. Biophys. Acta, 30, 281 (1959).

  11. 11

    Jacob, F., and Monod, J., J. Mol. Biol., 3, 318 (1961).

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Affiliations

  1. Department of Biochemistry, University of Cambridge

    • A. KORNER
    •  & A. J. MUNRO

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https://doi.org/10.1038/199489a0

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