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Stimulation by Rat Liver Ribonucleic Acid of Incorporation of Amino-acid into Rat Liver Ribosomes

Nature volume 199, pages 489–490 (1963)Cite this article

Abstract

THE discovery1 that ribonucleic acid (RNA) and synthetic polyribonucleotides stimulated the incorporation of amino -acids into protein-like material in cell-free system from E. coli has been followed by many reports2–6 of similar findings with systems from the same and other cells. Rat liver RNA was shown5 to stimulate amino-acid incorporation when added to an E. coli system and rat liver RNA and polyuridylic acid caused increased incorporation of phenylalanine in a rat-liver microsomal system6. We wish to report that polyuridylic acid and rat liver RNA stimulate incorporation of amino-acid with rat liver ribo-somes.

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References

  1. Nirenberg, M. W., and Matthaei, J. H., Proc. U.S. Nat. Acad. Sci., 47, 1588 (1961).

    Article  ADS  CAS  Google Scholar 

  2. Lengyel, P., Speyer, J. F., and Ochoa, S., Proc. U.S. Nat. Acad. Sci., 47, 1936 (1961).

    Article  ADS  CAS  Google Scholar 

  3. Arnstein, H. R. V., Cox, R. A., and Hunt, J. A., Biochem. J., 84, 918 (1962).

    Google Scholar 

  4. Ofengand, J., and Hazelkorn, R., Biochem. Biophys. Res. Comm., 6, 469 (1961).

    Article  Google Scholar 

  5. Barondes, S. H., Dingman, C. W., and Sporn, M. B., Nature, 196, 145 (1962).

    Article  ADS  CAS  Google Scholar 

  6. Maxwell, E. S., Proc. U.S. Nat. Acad. Sci., 48, 1639 (1962).

    Article  ADS  CAS  Google Scholar 

  7. Hall, B. D., and Doty, P., J. Mol. Biol., 1, 111 (1959).

    Article  CAS  Google Scholar 

  8. Brown Hill, T. J., Jones, A. S., and Stacey, M., Biochem. J., 73, 434 (1959).

    Article  CAS  Google Scholar 

  9. Korner, A., Biochem. J., 81, 168 (1961).

    Article  CAS  Google Scholar 

  10. Elson, D., Biochim. Biophys. Acta, 30, 281 (1959).

    Article  Google Scholar 

  11. Jacob, F., and Monod, J., J. Mol. Biol., 3, 318 (1961).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, University of Cambridge,

    A. KORNER & A. J. MUNRO

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  1. A. KORNER
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  2. A. J. MUNRO
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KORNER, A., MUNRO, A. Stimulation by Rat Liver Ribonucleic Acid of Incorporation of Amino-acid into Rat Liver Ribosomes. Nature 199, 489–490 (1963). https://doi.org/10.1038/199489a0

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