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Inhibition of Biological Synthesis of Acetylcholine by Triethylcholine

Naturevolume 199pages487488 (1963) | Download Citation



Bowman and Rand have suggested that the mechanism by which the triethyl analogue of choline causes failure of neuromuscular transmission is by interfering with synthesis of acetylcholine in the nerve endings1. If so. triethylcholine may be like HC-3 (hemicholinium), wilich has been found to inhibit the synthesis of acetylcholine by organized nerve tissue2,3.

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  1. 1

    Bowman, W. C., and Rand, M. J., Brit. J. Pharmacol., 17, 176 (1961).

  2. 2

    MacIntosh, F. C., Birks, R. I., and Sastry, P. B., Nature, 178, 1181 (1956).

  3. 3

    Gardiner, J. E., Biochem. J., 81, 297 (1961).

  4. 4

    Hebb, C. O., Handbook of Experimental Pharmacology, Supp., 15, edit. by Koelle, G. B. (Springer-Verlag, Berlin, 1963).

  5. 5

    Hebb, C. O., and Smallman, B. N., J. Physiol., 134, 385 (1956).

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  1. Agricultural Research Council Institute of Animal Physiology, Babraham, Cambridge

    • G. BULL
  2. Department of Pharmacology, School of Pharmacy, University of London, Brunswick Square, W.C.1



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