Abstract
A KNOWLEDGE of the levels of nicotinamide adenine nucleotide coenzymes in ruminant liver may be of value in understanding the ætiology of bovine ketosis and ovine pregnancy toxæmia. In particular, the possibility that a deficiency of the reduced form of the dinucleotide phosphate (NADPH2) may be associated with the hyperketonæmia which is characteristic of these metabolic disorders has been suggested by several workers1–4. Because NADPH2 is an essential cofactor for fatty acid biosynthesis5 a deficiency of it would result in impaired lipogenesis and consequently an increased ketogenesis6,7.
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PATTERSON, D. Nicotinamide Adenine Nucleotides in Ovine Liver. Nature 199, 402–403 (1963). https://doi.org/10.1038/199402b0
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DOI: https://doi.org/10.1038/199402b0
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