Abstract
IT has been shown that polyoma tumours induced in mice and in hamsters might contain a new cellular antigen1–4. The same phenomena were suggested in rats by comparative examination of the transplant-ability of polyoma and carcinogen-induced and spontaneous tumours in rats5. In the work reported here an attempt was made to demonstrate the presence of this antigen in transplantable polyoma tumours in rats and to verify its persistence in tissue cultures derived from primary polyoma tumours. The same antigen was also looked for in rat embryo fibroblasts which underwent a neoplastic transformation in vitro by the polyoma virus. No cytopathic effect was observed in this tissue culture, and no virus could be detected after the second in vitro passage.
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References
Sjögren, H. O., Hellström, I., and Klein, G., Cancer Res., 21, 329 (1961).
Sjögren, H. O., Virology, 15, 214 (1961).
Habel, K., Proc. Soc. Exp. Biol. Med., 106, 722 (1961).
Sachs, L., Exp. Cell Res., 24, 185 (1961).
Vandeputte, M., and De Somer, P., J. Gen. Microbiol., 29, 105 (1962).
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VANDEPUTTE, M., DE SOMER, P. Transplantation of Polyoma Tumours in Rats. Nature 199, 391–392 (1963). https://doi.org/10.1038/199391a0
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DOI: https://doi.org/10.1038/199391a0
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