Abstract
IT has been shown1 that histamine-induced peptic ulceration in the intact unanæsthetized guinea pig can be prevented or diminished by the oral administration of the sulphated polysaccharide, degraded carrageenan; severe duodenal ulceration could be completely prevented by a dose which at the same time approximately halved the severity of gastric ulceration. It was suggested that degraded carrageenan might augment the natural protection afforded by mucin by complexing with it, so providing a more robust mucosal coating. It has since also been found2 that in the guinea pig the volume and acidity of histamine gastric secretion is reduced by prior oral administration of degraded carrageenan
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References
Anderson, W., and Watt, J., J. Physiol., 147, 52 P (1959).
Anderson, W., Marcus, R., and Watt, J., J. Pharm. Pharmacol., 14, 119 T (1962).
Watt, J., Gastroenterol., 37, 741 (1959).
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ANDERSON, W., SOMAN, P. Degraded Carrageenan and Experimental Acute Gastric Ulceration in the Guinea Pig. Nature 199, 389 (1963). https://doi.org/10.1038/199389a0
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DOI: https://doi.org/10.1038/199389a0
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