Abstract
IN alloxan diabetes rates of glucose phosphorylation, glycolysis and pyruvate oxidation in rat heart and diaphragm muscles are subnormal, and evidence has been presented that these changes in carbohydrate metabolism are due to greater availability of fatty acids for oxidation in muscle in diabetes1,2. The evidence was that changes in carbohydrate metabolism, similar to those seen in muscle in diabetes, could be induced in normal muscle by in vitro addition of fatty acids2; and that measurements of glycerol output by rat heart and diaphragm muscles in vitro suggested that the breakdown of glycerides to free fatty acids and glycerol in muscle from diabetic rats was accelerated2,3. We have now sought to obtain more direct evidence for this idea by measuring the concentration of free fatty acids in these muscles.
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References
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GARLAND, P., RANDLE, P. Effects of Alloxan Diabetes and Adrenaline on Concentrations of Free Fatty Acids in Rat Heart and Diaphragm Muscles. Nature 199, 381–382 (1963). https://doi.org/10.1038/199381a0
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DOI: https://doi.org/10.1038/199381a0
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