Letter | Published:

Substance P Content and Effect on Capillary Permeability of Extract of Various Parts of Human Brain

Nature volume 199, pages 12951296 (28 September 1963) | Download Citation

Subjects

Abstract

CHEMICALLY pure substance P, apart from causing vasodilatation and stimulation of smooth muscle1, also increases capillary permeability2. We have now tested extracts of four parts of human brain, containing different amounts of substance P, for their effectiveness in increasing capillary permeability. The effects on the guinea pig ileum of acid-boiled extracts of substantia nigra, basal ganglia, cortex and cerebellum were compared with the effect of a standard preparation of substance P made from bovine intestine (for methods, see ref. 3). The results are listed in Table 1, col. 3. For estimating the effects of the brain extracts on capillary permeability, other vasoactive substances (acetyl choline, adrenergic amines, histamine, serotonin, ATP, ADP and AMP) had to be removed so far as possible; this was done by successive precipitations with ammonium sulphate and acetic acid-ether. The resulting ‘purified extracts’ were tested for activity in increasing capillary permeability of rabbit skin, using a modification of the method of Frimmer and Müller4.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , , and , Helv. Chim. Acta, 44, 881 (1961).

  2. 2.

    , Arch. Exp. Path. Pharmakol., 245, 276 (1963).

  3. 3.

    , and , Intern. Rev. Neurobiol., 4, 159 (1962).

  4. 4.

    , and , Med. Exp., 6, 327 (1962).

Download references

Author information

Affiliations

  1. Pharmakologisches Institut, University of Tübingen, Germany.

    • F. LEMBECK
    •  & K. STARKE

Authors

  1. Search for F. LEMBECK in:

  2. Search for K. STARKE in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/1991295a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.