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A Mucoid isolated from Bovine Red Cells exhibiting Strong Pneumococcus Type XIV Cross-reactivity

Naturevolume 199pages12891290 (1963) | Download Citation



IT is well known that all human and some animal red cells are agglutinated by anti-Type XIV pneumococcus serum1–3. The chemical nature of this phenomenon has been elucidated by Watkins and Morgan4 by means of hæmagglutination inhibition tests and has been interpreted as being due to the presence of O-β-D-galacto-pyranosyl-(1->4)-N-acetyl-D-glucosamine in terminal non-reducing position. This structure is considered to be an essential part of the human ABH—and Lewis blood group precursor substance, concluded from studies on the secreted material5.

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    Beeson, P. B., and Goebel, W. F., J. Exp. Med., 70, 239 (1939).

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    Watkins, W. M., and Morgan, W. T. J., Nature, 178, 1289 (1956).

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    Klenk, E., and Uhlenbruck, G., Z. Physiol. Chem., 311, 277 (1958).

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    Krüpe, M., and Ensgraber, A., Behring-Werk Mitt., 42, 48 (1962).

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  1. Physiol.-Chem. Institut der Universität Köln-Lindenthal, Germany

  2. Medizinaluntersuchungsstelle Fulda der Universität Marburg

    • M. KRÜPE


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