Letter | Published:

A Simple Preparation of 5-lodo-2'-deoxyuridine labelled with lodine-131 using Iodine Monochloride

Naturevolume 199page1285 (1963) | Download Citation



METHODS so far described for the preparation of 5-iodo-2′-deoxyuridine are based either on the iodination of deoxyuridine by free iodine in the presence of an oxidizing acid or free iodine in an alkaline medium1–3. The compound labelled with iodine-131 has been obtained by adapting the iodination in acid1,4 but the specific activity of the product has not been reported.

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  1. 1

    Cheong, L., Rich, M. A., and Eidinoff, M. L., J. Biol. Chem., 235, 1441 (1960).

  2. 2

    Prusoff, W. H., Biochim. Biophys. Acta, 32, 295 (1959).

  3. 3

    Prusoff, W. H., Jaffe, J. J., and Günther, H., Biochem. Pharmacol., 3, 110 (1960).

  4. 4

    Chang, P. K., and Welch, A. D., J. Med. Chem., 6, 428 (1963).

  5. 5

    Vogel, A. I., A Text-Book of Practical Organic Chemistry, second ed., 846 (Longmans, Green and Co.).

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  1. National Institute for Medical Research, Mill Hill, London, N.W.7



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