Letter | Published:

Induction of Melanotic Lesions of the Iris in Rats by Urethane given during the Neonatal Period

Naturevolume 199pages12011202 (1963) | Download Citation

Subjects

Abstract

THERE have been a number of reports in recent months of experiments in which animals have been exposed to chemical carcinogenic agents during the neonatal period1–6. It is probable that, on the basis of dose per unit of body-weight, newly born animals are particularly sensitive to tumour-induction. For example, lung tumours may be very readily induced in mice by the neonatal injection of small doses of certain weakly carcinogenic agents4. Because of this high sensitivity, the use of newly born animals for screening for carcinogenicity has been suggested3. Of possibly even greater interest, however, is the fact that animals injected when newly born with carcinogenic agents develop varieties of neoplasms not seen when the same agents are injected into adults of the same species and strain. For example, newly born ‘101’ strain mice injected with small doses of 9,10-dimethyl-1,2-benz-anthracene developed kidney tumours3. A further example of this type of phenomenon has recently come to light in an experiment in which rats were injected during the neonatal period with urethane (ethyl carbamate).

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Pietra, G., Spencer, K., and Shubik, P., Nature, 183, 1689 (1959).

  2. 2

    Pietra, G., Rappaport, H., and Shubik, P., Cancer, 14, 308 (1961).

  3. 3

    Roe, F. J. C., Rowson, K. E. K., and Salaman, M. H., Brit. J. Cancer, 15, 515 (1961).

  4. 4

    Roe, F. J. C., Mitchley, B. C. V., and Walters, M., Brit. J. Cancer, 17, 255 (1963).

  5. 5

    Fiore-Donati, L., Chieco-Bianchi, L., De Benedictus, G., and Maiorane, G., Nature, 190, 278 (1961).

  6. 6

    Kelly, M. G., and O'Gara, R. W., J. Nat. Cancer Inst., 26, 651 (1961).

  7. 7

    Tannenbaum, A., and Maltoni, C., Cancer Res., 22, 1105 (1962).

  8. 8

    Tannenbaum, A., Vesselinovitch, S. D., Maltoni, C., and Mitchell, D. S., Cancer Res., 22, 1362 (1962).

  9. 9

    Haddow, A., in Dr. Khanolkar Souvenir Volume (Indian Cancer Research Centre, Bombay, 1963) (in the press).

  10. 10

    Della Porta, G., Rappaport, H., Saffiotti, U., and Shubik, P., Amer. Med. Assoc. Arch. Path., 61, 305 (1956).

  11. 11

    Pietra, G., and Shubik, P., J. Nat. Cancer Inst., 25, 627 (1960).

  12. 12

    Nakai, T., and Rappaport, H., Nat. Cancer Inst. Monog. No. 10, 297 (1962).

  13. 13

    Fordner, J. G., and Allen, A. C., Cancer Res., 18, 98 (1958).

  14. 14

    Hartwell, J. L., Survey of Compounds which have been Tested for Carcinogenic Activity (U.S. Gov. Printing Office, Washington, D.C., 1951).

  15. 15

    Shubik, P., and Hartwell, J. L., Survey of Compounds which have been Tested for Carcinogenic Activity, Supp. 1 (U.S. Gov. Printing Office, Washington, D.C., 1957).

  16. 16

    Reese, A. B., Tumors of the Eye (Cassell, London, 1951).

  17. 17

    Ilif, C. E., and Ossofsky, H. J., Tumors of the Eye and Adnexia in Infancy and Childhood (Thomas, Springfield, Illinois, 1962).

  18. 18

    Zimmerman, L. E., Amer. J. Clin. Path., 39, 214 (1963).

Download references

Author information

Affiliations

  1. Department of Experimental Pathology, Chester Beatty Research Institute, Institute of Cancer Research, London, S.W.3

    • F. J. C. ROE
    •  & D. MILLICAN
  2. Department of Ophthalmology, Royal Marsden Hospital, London, S.W.3

    • J. M. MALLETT

Authors

  1. Search for F. J. C. ROE in:

  2. Search for D. MILLICAN in:

  3. Search for J. M. MALLETT in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/1991201a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.