Letter | Published:

Central Actions of Psychotomimetics

Naturevolume 199pages10031004 (1963) | Download Citation



ALTHOUGH the alterations in human behaviour and mental activity produced by psychotomimetic substances are not necessarily closely related to those observed in the psychoses1, the central modes of action of these substances are nevertheless of considerable interest. It is possible that drugs chemically related, to tryptamine, lysergic acid and the catecholamines block synaptic excitation in certain regions of the central nervous system, such as has been demonstrated in the lateral geniculate nucleus2. These substances may also mimic central inhibitory transmitters3, since certain derivatives depress the excitability of neurones in the cerebral cortex and thalamus4.

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    Krnjevic, K., and Phillis, J. W., J. Physiol., 165, 274 (1963). Andersen, P., Crawford, J. M., and Curtis, D. R. (unpublished observations).

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    Curtis, D. R., and Phillis, J. W., J. Physiol., 153, 17 (1960). Curtis, D. R., and Ryall, R. W. (unpublished observations).

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  1. Department of Physiology, Australian National University, Canberra

    • D. R. CURTIS
    •  & R. W. RYALL


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