Abstract
AFTER injection of heterologous antigen, antibody formation has been shown to occur in lymphoid tissues. Among the different lymphoid cell types, plasma cells contain a large amount of specific antibody as shown by the fluorescent antibody technique of Coons et al.1. It is therefore assumed that plasma cells form and secrete antibody into lymph and blood2. The buffy coat also contains immunologically competent cells. This fact is shown by the ability of these cells to induce a homograft reaction or to transfer delayed type hypersensitivity. Another form of immunological competence, antibody synthesis by peripheral blood leucocytes against a heterologous antigen, has not been demonstrated.
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References
Coons, A. H., Leduc, E. H., and Connolly, J. M., J. Exp. Med., 102, 49 (1955).
Fagraeus, A., Acta Med. Scand., 130, Supp. 204 (1948).
Sorkin, E., Rhodes, J. M., and Boyden, S. V., J. Immunol., 86, 101 (1961).
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HULLIGER, L., SORKIN, E. Synthesis of Antibodies by Blood Leucocytes of the Rabbit. Nature 198, 299 (1963). https://doi.org/10.1038/198299a0
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DOI: https://doi.org/10.1038/198299a0
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