Abstract
IT has long been known that the administration of methylcholanthrene by the alimentary tract can produce mammary tumours in certain strains of mice and rats. Prohaska, Brunschwig and Wilson1 first reported four mammary tumours in 15 mice fed 1.2 mg methylcholanthrene three times weekly for up to six weeks. Orr2 produced mammary carcinoma in mice to which methylcholanthrene was administered via the nares. Shay, Aegerter, Gruenstein and Komarov3 produced mammary tumours in Wistar rats given methylcholanthrene by gavage. Huggins, Briziarelli and Sutton4 reported on a large series of female Sprague–Dawley rats fed on methylcholanthrene 10 mg daily, who developed breast tumours in almost all cases. Dao and Sunderland5 confirmed that high incidence.
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References
Prohaska, J. van, Brunschwig, A., and Wilson, H., Arch. Surg. (Chicago), 38, 328 (1939).
Orr, J. W., J. Path. Bact., 55, 483 (1943).
Shay, H., Aegerter, E. A., Gruenstein, M., and Komarov, S. A., J. Nat. Cancer Inst., 10, 255 (1949).
Huggins, C., Briziarelli, G., and Sutton, jun., H., J. Exp. Med., 109, 25 (1959).
Dao, T. L., and Sunderland, H., J. Nat. Cancer Inst., 23, 567 (1959).
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GOODALL, A., McINTYRE, M. & KENNEDY, J. Metabolism of Radioactive Methylcholanthrene in the Rat. Nature 198, 1317–1318 (1963). https://doi.org/10.1038/1981317a0
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DOI: https://doi.org/10.1038/1981317a0
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