Abstract
Egyhazi and Hyden1 have reported that tricyano-amino-propene, a dimer of malononitrile, produced significant changes in nucleic acid and protein concentration in neurones and oligodendroglia. These results were obtained with a microelectrophoretic technique and supported previous observations obtained in work on malononitrile by Hartelius and Hyden2. In 1948 these investigators reported that malononitrile injected into rabbits produced an increase in the nucleoprotein content of neurones 1–24 h following injection. They also reported that malononitrile had a beneficial effect when administered to patients suffering from a variety of psychotic and depressive illnesses. Attempts to replicate these findings by a number of investigators3–5 were not successful. Experiments carried out by Mendelson et al.6 showed that the malononitrile preparation used by Hyden was not similar to freshly prepared solutions used by other investigators and that malononitrile in aqueous solution underwent degradation with formation of a new compound. This compound was isolated by Eberts7 and was identified as 1,1,3-tricyano-2-amino-1-propene (tri-a-p).
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References
Egyhazi, E., and Hyden, H. J., Biophys. and Biochem. Cytol., 10, 403 (1961).
Hartelius, H., and Hyden, H., Acta Psychiat. et Neurol., Supp. 48, 1 (1948).
Milzer, A., and Adelman, P., Proc. Soc. Exp. Biol. Med., 74, 134 (1950).
Myers, P., et al., Arch. Neurol. Psychiat., 63, 586 (1950).
Szanto, P. B., and Felsenfield, P., Proc. Soc. Exp. Biol. Med., 8, 257 (1950).
Mendelson, J., Mendelson, J. H., Fax, B. J., and Grenell, R. G., Science, 120, 266 (1954).
Eberts, jun., F. S., Biochem. Biophys. Res. Comm., 3, 107 (1960).
Grenell, R. G., and Hyden, H. (to be published).
Manjo, G., and Bunker, W. E., J. Neurochem., 2, 11 (1957).
McElroy, W. D., J. Biol. Chem., 191, 547 (1951).
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MENDELSON, J., WARMOTH, M. Effects of Tricyano-amino-propene on Metabolism of Isolated Cerebral Tissue. Nature 198, 1202–1203 (1963). https://doi.org/10.1038/1981202a0
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DOI: https://doi.org/10.1038/1981202a0
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