Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Comparative Investigation of the Free Nucleotides of an Ascitic Hepatoma and of Normal or Regenerating Liver

Nature volume 198, pages 1000–1001 (1963)Cite this article

Abstract

OUR investigations1,2 of the regulation of the biosynthesis of ribonucleic acids* in the cells of normal and cancerous rats led us to examine the pool of free nucleo tides in the ascitic hepatoma of Zajdela as well as in normal and regenerating liver. Normal liver represents an organ in a practically stationary state with differen tiated cells; regenerating liver represents a tissue where normal cells start proliferating, and the ascitic hepatoma, proliferating cells partially dedifferentiated.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Klein, N., Wintzerith, M., Mandel, L., and Mandel, P., J. Physiol. (Paris), 51, 499 (1959).

    CAS  Google Scholar 

  2. Revel, M., Mandel, L., Wintzerith, M., Klein, N., and Mandel, P., Bull. Soc. Chim. Biol., 43, 91 (1961).

    CAS  Google Scholar 

  3. Higgins, G. M., and Anderson, R. M., Arch. Pathol., 12, 186 (1931).

    Google Scholar 

  4. Chambon, P., and Mandel, P., Bull. Soc. Chim. Biol., 41, 715 (1959).

    CAS  Google Scholar 

  5. Cohn, W. E. J., Amer. Chem. Soc., 72, 1471 (1950).

    Article  CAS  Google Scholar 

  6. Hurlbert, R. B., Schmitz, H., Brumm, A. E., and Potter, V. R., J. Biol. Chem., 209, 23 (1954).

    PubMed  CAS  Google Scholar 

  7. Bourdet, A., and Mandel, P., C.R. Acad. Sci., Paris, 237, 530 (1953).

    CAS  Google Scholar 

  8. Paladini, A. C., and Leloir, L. F., Biochem. J., 51, 426 (1952).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre de Recherches Nucléaires, Applications Biologiques, Strasbourg-Cronenbourg,

    P. MANDEL, M. WINTZERITH, N. KLEIN-PETE & L. MANDEL

  2. Institut de Chimie Biologique, Faculté de Médecine, Strasbourg

    P. MANDEL, M. WINTZERITH, N. KLEIN-PETE & L. MANDEL

Authors
  1. P. MANDEL
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. WINTZERITH
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. KLEIN-PETE
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. MANDEL
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

MANDEL, P., WINTZERITH, M., KLEIN-PETE, N. et al. Comparative Investigation of the Free Nucleotides of an Ascitic Hepatoma and of Normal or Regenerating Liver. Nature 198, 1000–1001 (1963). https://doi.org/10.1038/1981000a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1981000a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing