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Sex Differences in the Pattern of Radioiodine Excretion in the Urine of Intact Stilbœstrol-treated Guinea Pigs

Nature volume 197, pages 801–802 (1963)Cite this article

Abstract

THE effects of oestrogen on intra-thyroidal iodine metabolism have been widely investigated1–3, but very little is known about its influence on the excretion of iodine in urine. In thyroidectomized castrated male rats on a daily maintenance dose of dl-thyroxine there is some indication that 50 µg of œstradiol benzoate daily for one week causes a slight retention of radioiodine1. Feldman3 has observed a decreased renal clearance of iodine-131 in both castrated and hypophysectomized rats receiving 500 I.U. of œstrone daily, but the decrease was not significant when compared with controls. It is most likely1,4 that oastrogen influences thyroidal activity by depression of renal excretion of iodine-131. It has also been reported that œstrogen influences the distribution of radioiodine in castrated male rats5.

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Author notes

  1. A. ŚLEBODZIŃSKI

    Present address: Agricultural Research Council Institute of Animal Physiology, Babraham, Cambridge

Authors and Affiliations

  1. Department of Biochemistry, Institute of Animal Husbandry, Cracow, Poland

    A. ŚLEBODZIŃSKI

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  1. A. ŚLEBODZIŃSKI
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ŚLEBODZIŃSKI, A. Sex Differences in the Pattern of Radioiodine Excretion in the Urine of Intact Stilbœstrol-treated Guinea Pigs. Nature 197, 801–802 (1963). https://doi.org/10.1038/197801a0

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