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Histamine-liberating Effect of Magnesium Deficiency in the Rat


DIETARY magnesium deficiency in the rat gives rise, after a few days, to a characteristic peripheral vasodilation with erythæma and œdema1. This change lasts for about a week, regresses and then re-appears later on. The signs of magnesium deficiency have been tentatively ascribed to a secondary vitamin B deficiency2 and have also been compared to human neurodermatitis3. However, it was shown recently that magnesium deficiency induces a decrease in the number of subcutaneous mast cells4, as well as an impairment in mast cell regeneration5. These observations are indicative of a change in histamine distribution that could be ascertained by measuring plasma and urinary histamine.

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  1. Kruse, H. D., Orent, E. R., and McCollum, E. V., J. Biol. Chem., 96, 519 (1932).

    Google Scholar 

  2. Greenberg, D. M., and Tufts, E. V., Amer. J. Physiol., 121, 416 (1938).

    CAS  Google Scholar 

  3. MacCardle, R. C., Engman, jun., M. F., and Engman, M. F., Arch. Dermat. Syph., 44, 429 (1941).

    Article  CAS  Google Scholar 

  4. Bélanger, L. F., Van Erkel, G. A., and Jakerow, A., Science, 126, 29 (1957).

    Article  ADS  Google Scholar 

  5. Bois, P., Byrne, E. H., and Bélanger, L. F., Canad. J. Biochem. Physiol., 38, 585 (1960).

    Article  CAS  Google Scholar 

  6. Van Reen, R., and Pearson, P. B., J. Nutr., 51, 191 (1953).

    Article  CAS  Google Scholar 

  7. Marshall, P. B., Brit. J. Pharmacol., 16, 50 (1961).

    PubMed  CAS  Google Scholar 

  8. Lowry, O. H., Graham, H. T., Harris, F. B., Priebat, M. K., Marks, A. R., and Bergman, R. U., J. Pharmacol. and Exv. Therap., 112, 116 (1954).

    CAS  Google Scholar 

  9. Feldberg, W., and Talesnik, J., J. Physiol., 120, 550 (1953).

    Article  CAS  Google Scholar 

  10. Riley, J. F., and West, G. B., J. Pathol. Bacteriol., 69, 269 (1955).

    Article  CAS  Google Scholar 

  11. MacIntyre, I., and Davidson, D., Biochem. J., 70, 456 (1958).

    Article  CAS  Google Scholar 

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BOIS, P., GASCON, A. & BEAULNES, A. Histamine-liberating Effect of Magnesium Deficiency in the Rat. Nature 197, 501–502 (1963).

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