DIETARY magnesium deficiency in the rat gives rise, after a few days, to a characteristic peripheral vasodilation with erythæma and œdema1. This change lasts for about a week, regresses and then re-appears later on. The signs of magnesium deficiency have been tentatively ascribed to a secondary vitamin B deficiency2 and have also been compared to human neurodermatitis3. However, it was shown recently that magnesium deficiency induces a decrease in the number of subcutaneous mast cells4, as well as an impairment in mast cell regeneration5. These observations are indicative of a change in histamine distribution that could be ascertained by measuring plasma and urinary histamine.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Kruse, H. D., Orent, E. R., and McCollum, E. V., J. Biol. Chem., 96, 519 (1932).
Greenberg, D. M., and Tufts, E. V., Amer. J. Physiol., 121, 416 (1938).
MacCardle, R. C., Engman, jun., M. F., and Engman, M. F., Arch. Dermat. Syph., 44, 429 (1941).
Bélanger, L. F., Van Erkel, G. A., and Jakerow, A., Science, 126, 29 (1957).
Bois, P., Byrne, E. H., and Bélanger, L. F., Canad. J. Biochem. Physiol., 38, 585 (1960).
Van Reen, R., and Pearson, P. B., J. Nutr., 51, 191 (1953).
Marshall, P. B., Brit. J. Pharmacol., 16, 50 (1961).
Lowry, O. H., Graham, H. T., Harris, F. B., Priebat, M. K., Marks, A. R., and Bergman, R. U., J. Pharmacol. and Exv. Therap., 112, 116 (1954).
Feldberg, W., and Talesnik, J., J. Physiol., 120, 550 (1953).
Riley, J. F., and West, G. B., J. Pathol. Bacteriol., 69, 269 (1955).
MacIntyre, I., and Davidson, D., Biochem. J., 70, 456 (1958).
Rights and permissions
About this article
Cite this article
BOIS, P., GASCON, A. & BEAULNES, A. Histamine-liberating Effect of Magnesium Deficiency in the Rat. Nature 197, 501–502 (1963). https://doi.org/10.1038/197501a0
This article is cited by
Magnesium metabolism and perturbations in the elderly
Geriatric Nephrology and Urology (1994)
Thymic lymphosarcoma in magnesium-deficient rats
Biological Trace Element Research (1979)
Tumour of the Thymus in Magnesium-deficient Rats
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.