Abstract
CLINICAL and pathological observations on Chinese hamsters (Cricetulus griseus) with spontaneous hereditary diabetes mellitus have been reported previously in several papers1–7. Generally speaking, the disease in Chinese hamsters is primarily pancreatogenic, with degranulation, hydropic degeneration and deficiency of β-cells. Other forms of pathological expression noted in symptomatic animals are glomerulosclerosis, arteriosclerosis, increased periodontal breakdown, and proneness toward the formation of adenocarcinomas of the pancreas.
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GREEN, M., YERGANIAN, G. & GAGNON, H. Prediction of Spontaneous Hereditary Diabetes Mellitus in Chinese Hamsters by Means of Elevated Alpha-2 Serum-levels. Nature 197, 396 (1963). https://doi.org/10.1038/197396a0
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DOI: https://doi.org/10.1038/197396a0
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