Abstract
RECENT work on the tumour-inhibiting action of 6-thioguanine (TG) has suggested strongly that growth inhibition is correlated with the incorporation of TG into the tumour nucleic acids, and particularly into DNA. Pre-treatment of tumour-bearing mice with azaserine (AS), an inhibitor of de novo purine synthesis, greatly enhanced the inhibitory action of TG, and this was associated with an increased incorporation of TG into the tumour nucleic acids1,2.
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ADAMS, D., BOWMAN, B. An Anti-Virus Action of Azaserine-Thioguanine in vivo. Nature 197, 316–317 (1963). https://doi.org/10.1038/197316a0
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DOI: https://doi.org/10.1038/197316a0
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