Abstract
PREVIOUS observations in this laboratory have indicated that the injection of catecholamines and certain posterior pituitary polypeptides into the lateral ventricle of the cat is associated with characteristic and drug-specific pressor–depressor responses of the peripheral circulation1. During the course of these earlier experiments, it was noted that the intraventricular introduction of posterior pituitary polypeptides was followed by a prompt increase of flow in urine. Other observers have reported that the peripheral administration of various posterior pituitary preparations may, on occasion, be attended by a rise of urine flow consequent to a solute diuresis2,3. The present experiments were designed to define certain aspects of the ‘diuretic’ effect of these drugs during their central administration.
Similar content being viewed by others
Article PDF
References
Nashold, B. S., Mannarino, E., and Wunderlich, M., Nature, 193, 1297 (1962).
Shannon, J. A., J. Exp. Med., 76, 387 (1942).
Smith, H. W., The Kidney : Structure and Function in Health and Disease (Oxford Univ. Press, 1951).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
NASHOLD, B., MANNARINO, E. & ROBINSON, R. Effect of Posterior Pituitary Polypeptides on the Flow of Urine after Injection in Lateral Ventricle of the Brain of a Cat. Nature 197, 293 (1963). https://doi.org/10.1038/197293a0
Issue Date:
DOI: https://doi.org/10.1038/197293a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.