Abstract
WHEN bacterial exotoxin, endotoxin, or snake venom is injected intravenously into animals, peripheral vascular collapse occurs. Preliminary investigations demonstrated that the administration of sub-lethal doses of Escherichia coli, Salmonella typhi or brucella endotoxins protected mice against lethal doses of snake venoms (Crotalus terrificus and Bothrops jararaca). Since North and Doery1 have reported that the venom of the Australian tiger snake (Notechis scutatus scutatus) protected mice against staphylococcal exotoxin, comparable work was carried out in our laboratory to determine if rattlesnake venom (Bothrops jararaca) would protect Swiss–Webster white mice against E. coli endotoxin, as well as staphylococcal toxin.
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References
North, E. A., and Doery, H. M., Nature, 181, 1542 (1958).
Staab, E. V., Condie, R. M., and Good, R. A., J. Exp. Med., 115, 579 (1962).
Thal, A. P., and Egner, W., J. Exp. Med., 113, 67 (1961).
Spink, W. W., and Vick, J., J. Exp. Med., 114, 501 (1961).
Doery, H. M., and North, B. A., Brit. J. Exp. Path., 41, 243 (1960).
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SPINK, W., SU, C. Failure to protect Mice against Endotoxin with Snake Venom. Nature 197, 88–89 (1963). https://doi.org/10.1038/197088a0
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DOI: https://doi.org/10.1038/197088a0
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