Abstract
SINCLAIR1 suggested in 1929 that phospholipids are obligatory intermediates in the absorption of fat. Later work by Zilversmit, Entenman and Chaikoff2 indicated, however, that there is little or no increase in turnover of the gross phospholipid fraction during absorption. Johnston and Bearden3 recently obtained evidence that a minor component, phosphatidic acid, has increased turnover during fat absorption in vitro. It seemed important, therefore, to examine the turnover of individual mucosal phospholipids during fat absorption in vivo, with special reference to phosphatidic acid.
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References
Sinclair, R. G., J. Biol. Chem., 82, 117 (1929).
Zilversmit, D. B., Entenman, C., and Chaikoff, I. L., J. Biol. Chem., 172, 637 (1948).
Johnston, J. M., and Bearden, J. H., Arch. Biochem. Biophys., 90, 57 (1960).
Dawson, E. M. C., Biochem. J., 75, 45 (1960).
Hübscher, G., Kemp, P., and Hawthorne, J. N., Lipid Res., 1, 433 (1960).
Clark, B., and Hübscher, G., Biochim. Biophys. Acta, 46, 479 (1961).
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GURR, M., POVER, W., HAWTHORNE, J. et al. Phospholipid Composition and Turnover in Rat Intestinal Mucosa during Fat Absorption. Nature 197, 79 (1963). https://doi.org/10.1038/197079a0
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DOI: https://doi.org/10.1038/197079a0
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