Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Mechanism of X-ray Inhibition of the Sodium Pump in Human Erythrocytes: Adenotriphosphatase Activity of Stromata

Nature volume 196, pages 186–187 (1962)Cite this article

Abstract

PREVIOUS results have shown that X-irradiation of human erythrocytes decreases the active efflux of sodium (sodium pump)1. However, 890 rads and 4,450 rads, which are effective in inducing a 45 and 73 per cent decrease of the active sodium efflux, respectively, do not inhibit glycolysis nor produce any effect on concentration of adenotriphosphate in red blood cells2. The lack of inhibition of the cellular system furnishing energy to the ion pump led us to investigate the biochemical mechanism in the membrane which underlies the active movement of sodium across the membrane.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Bresciani, F., Auricchio, F., and Fiore, C., Atti Soc. Ital. Patol. VII Cong. Bologna (1961); Biochem. Biophys. Res. Commun., 8, 492 (1962).

    Google Scholar 

  2. Bresciani, F., Auricchio, F., and Fiore, C. (to be published).

  3. Dunham, E. T., and Glynn, I. M., J. Physiol., 156, 274 (1961).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Post, R. L., Merrit, C. R., Kinsolving, G. R., and Albright, C. D., J. Biol. Chem., 235, 1796 (1960).

    CAS  PubMed  Google Scholar 

  5. Schatzmann, H. J., Helv. Physiol. Acta, 11, 346 (1953).

    CAS  Google Scholar 

  6. Herbert, E., J. Cell Comp. Physiol., 47, 11 (1956).

    Article  CAS  PubMed  Google Scholar 

  7. King, E. J., Biochem. J., 26, 292 (1932).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Hokin, L. E., and Hokin, M. R., J. Gen. Physiol., 44, 61 (1960).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Hokin, L. E., and Hokin, M. R., Nature, 189, 836 (1961).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

Author information

Author notes

  1. FRANCESCO BRESCIANI

    Present address: Department of Biology, Brookhaven National Laboratory, Upton, Long Island, New York

Authors and Affiliations

  1. Institute of General Pathology, University of Naples,

    FRANCESCO BRESCIANI, FERDINANDO AURICCHIO & CESARE FIORE

Authors
  1. FRANCESCO BRESCIANI
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. FERDINANDO AURICCHIO
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. CESARE FIORE
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BRESCIANI, F., AURICCHIO, F. & FIORE, C. Mechanism of X-ray Inhibition of the Sodium Pump in Human Erythrocytes: Adenotriphosphatase Activity of Stromata. Nature 196, 186–187 (1962). https://doi.org/10.1038/196186a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/196186a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing