Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Experimental Production of Mesothelial Tumours of the Pleura by Implantation of Dusts in Laboratory Animals


IN view of the possible association between the development of mesotheliomas of the pleura and exposure to asbestos dust in people living in the Cape asbestos fields1,2, a preliminary experiment was undertaken to see if it was possible to produce mesotheliomas, in animals, by injecting various forms of asbestos into the pleural cavities. 110 young rats, mice, and guinea pigs were used. The experiment has not yet been concluded as 45 of the guinea pigs, and four of the rats, are still alive thirty months after the start of the experiment. This is a preliminary report of our positive findings in 106 rats which have either died or have been killed.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. Wagner, J. C., Sleggs, C. A., and Marchand, P., Brit. J. Indust. Med., 17, 260 (1960).

    CAS  Google Scholar 

  2. Sleggs, C. A., Marchand, P., and Wagner, J. C., S. Afr. Med. J., 35, 28 (1961).

    Google Scholar 

  3. Harington, J. S., Nature, 193, 43 (1962).

    ADS  Article  Google Scholar 

  4. Ratcliffe, H. L., Amer. J. Path., 16, 237 (1940).

    CAS  PubMed  Google Scholar 

  5. Wagner, J. C., Munday, D. E., and Harington, J. S., J. Path. Bact., 84, 73 (1962).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

WAGNER, J. Experimental Production of Mesothelial Tumours of the Pleura by Implantation of Dusts in Laboratory Animals. Nature 196, 180–181 (1962).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing