Abstract
DOSE-RESPONSE curves for the influence of ionizing radiations on in vitro incorporation of DNA precursors into human bone marrow1 and experimental tumours2,3 irradiated in the period of synthesis of DNA are well known. Recently published investigations4 showed a striking similarity between these curves for human bone marrow and Ehrlich ascites carcinoma while both systems were oxygenated. Our experiments show the relationship between the dose of X-rays and the depression of thymidine incorporation in anoxic suspensions of rat bone marrow and Ehrlich ascites tumour.
Similar content being viewed by others
Article PDF
References
Lajtha, L. G., Oliver, R., Berry, R., and Noyes, W. D., Nature, 182, 1788 (1958).
Berry, R. J., Hell, E., Lajtha, L. G., and Ebert, M., Nature, 186, 563 (1960).
Maass, H., and Künkel, H. A., Intern. J. Rad. Biol., 2, 269 (1960).
Berry, R. J., Hell, E., Lajtha, L. G., and Ebert, M., Intern. J. Rad. Biol., 4, 61 (1961).
Michalowski, A., and Jasinska, J., Radiobiologia Radiotherapia (in the press).
Jasinska, J., and Michalowski, A. (unpublished results).
Lajtha, L. G. (personal communication, 1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
JASINSKA, J., MICHALOWSKI, A. Influence of X-rays on the Incorporation of Deoxyribonucleic Acid Precursors into some Mammalian Cells in vitro. Nature 196, 1326 (1962). https://doi.org/10.1038/1961326a0
Issue Date:
DOI: https://doi.org/10.1038/1961326a0
This article is cited by
-
DNA synthesis in nuclei and nuclear matrices of regenerating rat liver: Effect of whole-body gamma irradiation
Radiation and Environmental Biophysics (1991)
-
Radiation-induced Inhibition of Thymidine Incorporation by Mammalian Cells in vitro
Nature (1966)
-
Inhibition of DNA Synthesis by Ultra-Violet Light Under Controlled Temperature
Nature (1966)
-
Organization of the Deoxyribonucleic Acid Replicating System in Mammalian Cells as Revealed by the Use of X-Radiation and Bromuracil Deoxyriboside
Nature (1964)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.