Abstract
IT was shown by Tanaka et al.1,2 that 5-arylazo pyrimidines having different groups (for example, hydroxyl, methyl or amino) at the 2, 4 and 6 positions are strong folio acid antagonists and that some of these possess marked anti-neoplastic properties. They also found that the nature of substituents in the benzene ring of the phenylazo radical was the determining factor for this activity.
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References
Tanaka, K., et al., Acta Unio. Intern. contre Cancrum, 15, 281 (1959).
Tanaka, K., et al., Chem. and Pharm. Bull. (Tokyo), 7, 1 (1959).
Roy-Burman, P., Roy, D., and Sen, D., Naturwiss., 47, 515 (1960).
Roy-Burman, P., Sen, D., and Guha, B. C., Naturwiss., 48, 737 (1961).
Methods of Vitamin Assay, second ed. (Interscience Pub., Inc., 1951).
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ROY-BURMAN, P., SEN, D. N-(5-Arylazo-4-Pyrimidyl)-Amino-Acids as Growth Inhibitors of Streptococcus faecalis. Nature 196, 1316 (1962). https://doi.org/10.1038/1961316a0
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DOI: https://doi.org/10.1038/1961316a0
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