Abstract
Amin and Mehta have claimed1 that vasicinone (I), which they obtained by aerial oxidation in sunlight of crude extracts of Adhatoda vasica or of pure vasicine (II), the shrub's main alkaloid, has a bronchodilating action. They suggested that this property is attributable to the quinazol-4-one ring system for they found it to be common to the parent substance (III) and various simple derivatives2. Vasicine, on the other hand, proved to have a bronchoconstricting action, and the bronchodilator effects variously attributed3 to preparations containing it they ascribed to contamination by small amounts of vasicinone.
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References
Amin, A. H., and Mehta, D. R., Nature, 184, 1317 (1959).
Amin, A. H., Mehta, D. R., and Samarth, S. S., Proc. First Intern. Pharmacol., 488 (1961).
Chopra's Indigenous Drugs of India, second ed., revised by Chopra, R. N., Chopra, I. C., Hand,K. L., and Kapur, L. D., 265 (Calcutta, 1958).
Holgate, J. A., and Warner, B. T., Brit. J. Pharmacol., 15, 561 (1960).
Southwick, P. L., and Cremer, S. E., J. Org. Chem., 24, 753 (1959).
Sharapov, I. M., Farmakologiya i Toksikologiya, 22/1, 67 (1959).
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CAMBRIDGE, G., JANSEN, A. & JARMAN, D. Bronchodilating Action of Vasicinone and Related Compounds. Nature 196, 1217 (1962). https://doi.org/10.1038/1961217a0
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DOI: https://doi.org/10.1038/1961217a0
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