Abstract
CARDIAC muscle demonstrates great flexibility in the choice of substrates for energy production under various conditions. By coronary sinus catheterization of the intact heart in dogs1 and man2,3, it has been shown that under conditions of fasting or diabetes mellitus, the heart's principal sources of fuel are fatty acids derived from the non-esterified fraction of plasma, whereas after a carbohydrate-rich meal, glucose, pyruvate, and lactate are the preferred sources of energy. Under these latter conditions of rising concentrations of glucose and the three-carbon acids, the extraction of non-esterified fatty acids by the heart may drop to nil.
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OLSON, R. Effect of Pyruvate and Acetoacetate on the Metabolism of Fatty Acids by the Perfused Rat Heart. Nature 195, 597–599 (1962). https://doi.org/10.1038/195597b0
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DOI: https://doi.org/10.1038/195597b0
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