Abstract
FOLLOWING the administration of a wide variety of drugs such as psychoactive agents (reserpine, chlorpromazine, imipramine), sympathomimetic amines (tyramine, amphetamine), cocaine, adrenergic blocking agents (phenoxybenzamine), and hypotensive drugs (guanethidine) a lower concentration of injected 3H-noradrenaline was found in the heart, spleen and adrenal glands1–3. Most of these drugs also increase the rate of metabolism of 3H-noradrenaline in the whole mouse presumably by preventing the protective binding of the hormone and exposing it to enzymatic attack4,5. Although these drugs have many actions, they could produce a common-end result by different mechanisms. They might lower the tissue levels of 3H-noradrenaline by blocking the entry of the circulating catecholamine into the storage site, preventing the binding or causing the release of the bound 3H-noradrenaline or by a combination of these.
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Whitby, L. G., Hertting, G., and Axelrod, J., Nature, 187, 604 (1960).
Axelrod, J., Whitby, L. G., and Hertting, G., Science, 133, 383 (1961).
Hertting, G., Axelrod, J., and Whitby, L. G., J. Pharmacol. Exp. Therap., 134, 146 (1961).
Axelrod, J., and Tomchick, R., Nature, 184, 2027 (1959).
Axelrod, J., and Tomchick, R., J. Pharmacol. Exp. Therap., 130, 367 (1960).
Whitby, L. G., Axelrod, J., and Weil-Malherbe, H., J. Pharmacol. Exp. Therap., 132, 193 (1961).
Hertting, G., Axelrod, J., and Patrick, R. W., Biochem. Pharmacol., 8, 246 (1961).
Axelrod, J., Hertting, G., and Patrick, R. W., J. Pharmacol. Exp. Therap., 134, 325 (1961).
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AXELROD, J., HERTTING, G. & POTTER, L. Effect of Drugs on the Uptake and Release of 3H-Norepinephrine in the Rat Heart. Nature 194, 297 (1962). https://doi.org/10.1038/194297a0
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DOI: https://doi.org/10.1038/194297a0
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