Abstract
THE introduction by Ramsdell1 of the use of vital dyes for demonstrating increase in capillary permeability in local anaphylactic reaction opened up a whole new field of investigation of this phenomenon in experimental animals2,3. The characteristics required in dyes for such purpose are low toxicity, retention within the blood vessels for a reasonable period and the ability to diffuse out with the blood plasma when a local increase in capillary permeability permits escape of the latter into the tissues.
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References
Ramsdell, S. G., J. Immunol., 15, 305 (1928).
Ovary, Z., Prog. Allergy, 5, 459 (1958).
Rosenberg, L. T., Rev. Allergy App. Immunol., 12, 710 (1958).
Feinberg, J. G., Nature, 191, 712 (1961).
Feinberg, J. G., and Dewdney, J. M., Meeting Brit. Soc. Immunol. (Nov. 1961).
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FEINBERG, J., DEWDNEY, J. Use of a Non-persisting Dye for demonstrating Local Anaphylaxis. Nature 194, 199 (1962). https://doi.org/10.1038/194199a0
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DOI: https://doi.org/10.1038/194199a0
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