Abstract
PREVIOUS work1 has indicated the importance of cell division for antibody production in an in vitro spleen cell system. These findings prompted an investigation of the factors affecting the synthesis of deoxyribonucleic acid (DNA) in these preparations. The experiments described here demonstrate that the addition of antigen to the incubation medium stimulates the synthesis of DNA in spleen cells from previously immunized rabbits. The stimulation is antigen-specific.
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References
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DUTTON, R., PEARCE, J. Antigen-dependent Stimulation of Synthesis of Deoxyribonucleic Acid in Spleen Cells from Immunized Rabbits. Nature 194, 93–94 (1962). https://doi.org/10.1038/194093a0
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DOI: https://doi.org/10.1038/194093a0
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