Abstract
PATTLE1 first noted the stability of bubbles formed in the foam expressed from lungs of mature animals and the lack of stability in material from fœtal lungs. Clements2 emphasized the importance of a bubblestabilizing factor, that is, a surfactant, in the prevention of atelectasis. Lungs from human fœtuses of less than 1,000 gm. usually lack the surfactant characteristic of older fœtuses3; occasionally, lessmature fœtuses possess lung stability4.
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References
Pattle, R. E., Proc. Roy. Soc., B, 148, 217 (1958).
Clements, J. A., Proc. Soc. Exp. Biol. and Med., 95, 170 (1957).
Avery, M. E., and Mead, J., Amer. J. Dis. Child., 97, 517 (1959).
Gruenwald, P., Lancet, i, 230 (1960).
Pattle, R. E., Nature, 189, 844 (1961). Buckingham, S., Thirty-first Ann. Meet. Soc. Ped. Res. May 4–5, 1961, Prog. and Abst., 68. Klaus, M., Clements, J., and Havel, R. J., Seventy-first Ann. Meet. Amer. Ped. Soc., May 2–3, 1961, Prog. and Abst., 28.
Macklin, C. H., Lancet, i, 1099 (1954).
Woodside, G. L., and Dalton, A. J., J. Ultrastructure Res., 2, 28 (1958).
Schulz, H., The Submicroscopic Anatomy and Pathology of the Lung (Springer, Berlin, 1959).
Clements, J. A., Hustead, R. F., Johnson, R. P., and Gribetz, I., J. App. Physiol., 16, 444 (1961).
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BUCKINGHAM, S., AVERY, M. Time of Appearance of Lung Surfactant in the Fœtal Mouse. Nature 193, 688–689 (1962). https://doi.org/10.1038/193688a0
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DOI: https://doi.org/10.1038/193688a0
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