Letter | Published:

Sub-cellular Distribution of the Substance P in the Nervous Tissues

Naturevolume 193page585 (1962) | Download Citation

Subjects

Abstract

Hebb and Whittaker1 have described the isolation of a sub-cellular fraction of brain tissue which contains bound acetylcholine and choline acetylase. This fraction was examined further by Whittaker2 with equilibrium centrifugation in a density gradient. His results appear to provide evidence for physiological significance of his “synaptic vesicle fraction”. We have also attempted to apply his fractionation method to study sub-cellular distribution of substance P in the nervous system.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Hebb, C. O., and Whittaker, V. P., J. Physiol., 142, 187 (1958).

  2. 2

    Whittaker, V. P., Biochem. J., 72, 694 (1959).

  3. 3

    Euler, U. S. v., Acta Physiol. Scand., 4, 373 (1942).

  4. 4

    Lowry, O. H., Rosebrough, N. I., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).

  5. 5

    Amin, A. H., Crawford, T. B. B., and Gaddum, J. H., J. Physiol., 126, 596 (1954).

  6. 6

    Pernow, B., Acta Physiol. Scand., 29, Supp., 105 (1953).

  7. 7

    Toschi, G., Exp. Cell Res., 16, 232 (1959).

  8. 8

    Aldridge, W. N., and Johnson, A., Biochem. J., 73, 270 (1959).

  9. 9

    Tsujioka, T., J. Physiol. Soc. Jap., 20, 662 (1958).

  10. 10

    Krivoy, W. A., Brit. J. Pharmacol., 12, 361 (1957).

  11. 11

    Inouye, A., Kataoka, K., and Tsujioka, T., Jap. J. Physiol., 11, 319 (1961).

Download references

Author information

Affiliations

  1. Department of Physiology, Faculty of Medicine, Kyoto University, Kyoto, Japan

    • AKIRA INOUYE
    •  & KIYOSHI KATAOKA

Authors

  1. Search for AKIRA INOUYE in:

  2. Search for KIYOSHI KATAOKA in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/193585a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.