Letter | Published:

Sub-cellular Distribution of the Substance P in the Nervous Tissues

Naturevolume 193page585 (1962) | Download Citation



Hebb and Whittaker1 have described the isolation of a sub-cellular fraction of brain tissue which contains bound acetylcholine and choline acetylase. This fraction was examined further by Whittaker2 with equilibrium centrifugation in a density gradient. His results appear to provide evidence for physiological significance of his “synaptic vesicle fraction”. We have also attempted to apply his fractionation method to study sub-cellular distribution of substance P in the nervous system.

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  1. 1

    Hebb, C. O., and Whittaker, V. P., J. Physiol., 142, 187 (1958).

  2. 2

    Whittaker, V. P., Biochem. J., 72, 694 (1959).

  3. 3

    Euler, U. S. v., Acta Physiol. Scand., 4, 373 (1942).

  4. 4

    Lowry, O. H., Rosebrough, N. I., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).

  5. 5

    Amin, A. H., Crawford, T. B. B., and Gaddum, J. H., J. Physiol., 126, 596 (1954).

  6. 6

    Pernow, B., Acta Physiol. Scand., 29, Supp., 105 (1953).

  7. 7

    Toschi, G., Exp. Cell Res., 16, 232 (1959).

  8. 8

    Aldridge, W. N., and Johnson, A., Biochem. J., 73, 270 (1959).

  9. 9

    Tsujioka, T., J. Physiol. Soc. Jap., 20, 662 (1958).

  10. 10

    Krivoy, W. A., Brit. J. Pharmacol., 12, 361 (1957).

  11. 11

    Inouye, A., Kataoka, K., and Tsujioka, T., Jap. J. Physiol., 11, 319 (1961).

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  1. Department of Physiology, Faculty of Medicine, Kyoto University, Kyoto, Japan



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