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Ganglioside in Maturing Rat Brain

Naturevolume 193pages580581 (1962) | Download Citation



THE cerebral cortex is characterized in part by its large content of glycolipid material called gangliosides. These substances were first noted in brain by Klenk1. Later they were extensively studied by Folch et al.2,3 who have used the term ‘strandin’ for their preparations. Brain gangliosides have been shown to contain hexoses, hexosamines, N-acetylneuraminic acid (NANA) and ceramides. There are strong indications that amino-acids are joined to the glycolipid in situ2. Because of different procedures and the use of divergent species, workers have not been able to agree on the exact concentrations of the various components. Bogoch4, on the basis of hydrolytic studies, has proposed a basic unit structure for ox-brain ganglioside. Klenk and Gielen5 have suggested a smaller, though similar, unit. Both authors indicate that there should be a stoichiometric relationship among the components of mature brain ganglioside.

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  1. 1

    Klenk, E., Hoppe-Seyl. Z., 273, 76 (1942).

  2. 2

    Lebaron, F. N., and Folch, J., Physiol. Rev., 37, 554 (1957).

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    Folch, J., Lees, M., and Stanley, G. H. S., J. Biol. Chem., 228, 497 (1957).

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    Klenk, E., and Gielen, E., Hoppe-Seyl. Z., 319, 283 (1960).

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    Anastassiadis, P. A., and Common, R. H., Canad. J. Biochem. Physiol., 36, 413 (1958).

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    Haab, W., and Anastassiadis, P. A., Canad. J. Biochem. Physiol., 39, 671 (1961).

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  1. Department of Biochemistry, Faculty of Medicine, University of Alberta, Edmonton, Alberta

    •  & P. L. CANTIN


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