Letter | Published:

Accumulation of S-Sulphocysteine by a Mutant Strain of Aspergillus nidulans

Naturevolume 193pages481482 (1962) | Download Citation



RECENT work in this laboratory1,2, together with earlier observations by Hockenhull3, have provided strong evidence indicating that in Aspergillus nidulans cysteine is synthesized from inorganic sulphur sources via S-sulphocysteine (cysteine-S-sulphonate) as the immediate precursor. This latter compound has, however, not yet been reported to occur in micro-organisms. In the present communication we report that a mutant strain of A. nidulans actually accumulates radioactive S-sulphocysteine when grown in a medium containing sulphate labelled with sulphur-35. The mutant used, strain 793, has been shown to be genetically blocked in the reaction by which S-sulphocysteine is converted to cysteine1,2.

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  1. 1

    Nakamura, T., and Sato, R., Nature, 185, 163 (1960).

  2. 2

    Nakamura, T., J. Gen. Microbiol. (in the press).

  3. 3

    Hockenhull, D. J. D., Biochim. Biophys. Acta, 3, 326 (1949).

  4. 4

    Harada, T., and Spencer, B., J. Gen. Microbiol., 22, 520 (1960).

  5. 5

    Marrian, D. H., J. Chem. Soc., 1515 (1949).

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  1. Institute for Protein Research, Osaka University, Kita-Ku, Osaka, Japan

    •  & RYO SATO


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