Letter | Published:

Absorption and Excretion of Penicillin injected into the Muscles of Patients with Diabetes Mellitus

Naturevolume 192pages987988 (1961) | Download Citation



THE observation that two patients with sub-acute bacterial endocarditis due to alpha-streptococci highly sensitive to penicillin in vitro failed to respond to administration of six million units of the drug a day led to investigations which revealed low peak blood-levels and abnormal urinary excretion of the antibiotic in both. When the dose of penicillin was increased to a quantity greatly in excess of that suggested by the test-tube sensitivity of the organisms, favourable clinical response followed promptly. Other than the endocarditis, the only finding common to both individuals was the presence of diabetes mellitus. Since a review of published information concerning the pharmacology of penicillin1–4 revealed no data indicating any abnormalities related to the diabetic state, it was decided to investigate this problem.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Broderson, R., and Anderson, W. H., Proc. Soc. Exp. Biol. and Med., 71, 639 (1949).

  2. 2

    Bryner, S., Clark, W. H. Randall, and Rantz, L. A., Amer. J. Med., 5, 202 (1948).

  3. 3

    Eagle, H., Fleischman, R., and Musselman, A. D., J. Bact., 57, 119 (1948).

  4. 4

    Schwartz, B. S., Lewis, M. N., and Ercoli, N., Amer. J. Med. Sci., 219. 617 (1950).

Download references

Author information


  1. Department of Medicine, Tufts University School of Medicine

  2. New England Center Hospital, Boston, Massachusetts

    • R. H. MEADE


  1. Search for L. WEINSTEIN in:

  2. Search for R. H. MEADE in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.