Abstract
EXCESS protein and deoxyribonucleic acid (DNA) are found in chronic hepatic injury, for example, after administration of ethionine1–3, butter yellow4,5, 2 acetyl aminofluorene6,7, and a high fat–low choline–low protein diet1. This suggested that the excess protein or DNA is an abnormal product of the hepatocytes1–3. This is supported by the incorporation of ethionine into hepatic, proteins2, presumably the abnormal proteins. These proteins, or DNA, have been related to cancer1,7. This communication is to point out that the excess protein formation results from alterations in cell population, rather than from formation of abnormal proteins.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Farish, P. T., Salmon, W. D., and Sauberlich, H. E., Nutrition, 73, 23 (1961).
Stekol, J. A., Mody, U., and Perry, F., J. Biol. Chem., 235, 59 (1960).
Levine, M., and Fopeano, jun., J. V., J. Biol. Chem., 202, 597 (1953).
Price, J. M., Miller, E. C., and Miller, J. A., J. Biol. Chem., 173, 345 (1948).
Miller, E. C., and Miller, J. A., J. Nat. Cancer Inst., Supp., 15, 1571 (1955).
Laird, A. K., and Miller, E. C., Cancer Res., Supp. 1, 13, 464 (1953).
Rutman, R. J., Cantarow, A., and Paschkis, K. E., Cancer Res., 14, 111 (1954).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
RUBIN, E., HUTTERER, F., GALL, E. et al. Nature of Increased Protein and DNA in Chronic Hepatic Injury. Nature 192, 886–887 (1961). https://doi.org/10.1038/192886a0
Issue Date:
DOI: https://doi.org/10.1038/192886a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.