Letter | Published:

5′-Adenylic Acid Deaminase in Dystrophic Mouse Muscle

Naturevolume 192pages884885 (1961) | Download Citation



THE discovery1, in 1955, of a hereditary myopathy in a strain of mice has provided a useful subject for the investigation of muscular dystrophy. Although the ultimate cause of the mouse disease may not be identical with the cause of any of the human muscular dystrophies, it is a reasonable assumption that many of the secondary changes will be similar. A number of workers have reported quantitative enzyme changes in the dystrophic mouse muscle. Some activities, for example, cathepsins2 and glucose-6-phosphate dehydrogenase3, show an increase; others, for example, lactic dehydrogenase4 and phosphorylase5, are decreased.

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  1. 1

    Michelson, A. M., Russell, E. S., and Harman, P. J., Proc. U.S. Nat. Acad. Sci., 41, 1079 (1955).

  2. 2

    Weinstock, I. M., Epstein, S., and Milhorat, A. T., Proc. Soc. Exp. Biol. N.Y., 99, 272 (1958).

  3. 3

    McCaman, M. W., Science, 132, 621 (1960).

  4. 4

    White, L. P., Calif. Med., 90, 1 (1959).

  5. 5

    Leonard, S. L., Proc. Soc. Exp. Biol., N.Y., 96, 720 (1957).

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  1. Departments of Pathology (Medical Biochemistry) and Medicine (Neurology), King's College, (University of Durham), and Royal Victoria Infirmary, Newcastle upon Tyne



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