Letter | Published:

Release of Noradrenaline from the Spleen of the Cat by Acetylcholine

Nature volume 192, pages 880881 (02 December 1961) | Download Citation

Subjects

Abstract

ACETYLCHOLINE contracts the spleen of the dog1 and cat2. In these species the effect of acetylcholine in contracting the spleen is not blocked by atropine, but is blocked by dibenzyline and reduced by prior treatment of the animal with reserpine; thus it appears that the action of acetylcholine may be mediated by releasing noradrenaline from its stores in the spleen, which afterwards causes a contraction. The work reported here provides further evidence that acetylcholine liberates noradrenaline from the cat spleen.

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References

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Author information

Author notes

    • HELEN BOYD

    Present address: Department of Zoology, University of Melbourne, Victoria, Australia.

Affiliations

  1. Department of Pharmacology, University of Sydney, New South Wales.

    • K. W. BRANDON
    •  & HELEN BOYD

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DOI

https://doi.org/10.1038/192880a0

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