Abstract
DETAILED and extensive investigations of the metabolism of polycyclic hydrocarbons have been carried out over many years, but it is only recently that information linking the metabolism of these agents with an enzymic system present in liver has become available. It has been found that hydroxylation of the carcinogenic 3 : 4 benzpyrene1 and the non-carcinogenic naphthalene2 is brought about by an enzyme, or ‘hydroxylase’1, which occurs in the microsomal fraction of liver homogenates, this system requiring reduced triphosphopyridine nucleotide and molecular oxygen for activity. One of us (K. H. H.) has found that the same or a similar system is also active against pyrene and 1 : 2 benzanthracene. The products obtained are similar to those obtained during in vivo metabolism. This work will be reported in detail elsewhere.
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HARPER, K., CALCUTT, G. In vivo and in vitro Inhibition of Aromatic Hydroxylation by Riboflavin. Nature 192, 165–166 (1961). https://doi.org/10.1038/192165a0
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DOI: https://doi.org/10.1038/192165a0
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