Letter | Published:

Effect of X-Irradiation on Self-Stimulation of the Brain

Nature volume 192, page 1307 (30 December 1961) | Download Citation

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Abstract

RECENTLY it has been shown that the brain is sensitive to low doses of ionizing radiation1,2. Prolonged exposure to X-irradiation decreases lever-pressing by rats3. Conditional aversion to saccharin results from exposure of rats to γ-radiation4,5. Because radiation affects psychological tests based upon food or fluid intake, we studied the effects of X-irradiation on rats trained to press a lever for electrical stimulation of the brain6. A single electrode was permanently implanted in the posterior hypothalamus of 8 CFN rats. After a training period of 6 months, the rats received 600 r. acute whole-body X-irradiation. Radiation characteristics were : 250 kVp.; 15 m.amp.; focus-object distance 70 cm.; filters, 0.21 mm. copper inherent, 0.5 mm. copper parabolic and 1.0 mm. aluminium; half-value layer 1.92 mm. copper; 22.9 r./min. measured in air.

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Author information

Affiliations

  1. Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, University of California at Los Angeles.

    • THOMAS J. HALEY
    • , P. BACH-Y-RITA
    •  & N. KOMESU

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DOI

https://doi.org/10.1038/1921307a0

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