Letter | Published:

A Carcinogenic Action of Testosterone, provoking Uterine Tumours in Mice

Naturevolume 192page1303 (1961) | Download Citation



THE literature concerning the induction of tumours by hormones is very extensive1–4. Œstrogens especially appeared to play an important part in hormonal carcinogenesis5. Evidence of a carcinogenic action of androgens is very scant. Horning6 observed 3 theca-cell ovarian tumours in rats and 2 adrenal cortical tumours in hamsters after long-term treatment with testosterone. Also, Kirkman7 suggested that testosterone propionate may act as a non-specific carcinogen in the hamster.

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  1. 1

    Gardner, W. U., Adv. Cancer Res., 1, 173 (1953).

  2. 2

    Kirschbaum, A., Cancer Res., 17, 432 (1957).

  3. 3

    Bielschowsky, F., and Horning, E. S., Brit. Med. Bull., 14, 106 (1958).

  4. 4

    Gardner, W. U., Pfeiffer, C. A., and Trentin, J. J., in The Physiopathology of Cancer, second ed., edited by Hamburger, F., and Fishman, W. H., 152 (Hoeber, New York, 1959).

  5. 5

    Burrows, H., and Horning, E. S., Oestrogens and Neoplasia (Blackwell Scientific Publications, Oxford, 1952).

  6. 6

    Horning, E. S., Brit. J. Cancer, 12, 414 (1958).

  7. 7

    Kirkman, H., Acta Un. Int. Cancer, 16, 143 (1960).

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  1. Laboratory Antoni van Leeuwenhoek-huis, Netherlands Cancer Institute, Amsterdam

    • R. VAN NIE
    • , E. L. BENEDETTI
    •  & O. MÜHLBOCK


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