Letter | Published:

Serological Evidence of a Chromatographic Sub-fractionation of Human 7S γ-Globulin

Naturevolume 192pages13011302 (1961) | Download Citation



PREPARATIONS consisting of the electrophoretically slowest migrating part of the 7S γ-globulin were prepared by means of preparative zone electrophoresis. Individual preparations were obtained from normal serum and from the serum of an Rh-immunized individual. Preparations from pooled plasma were obtained from commercially available Cohn fractionated γ-globulin (supplied by AB KABI, Stockholm). All preparations showed Gm(a+) character when tested in a serum-grouping system according to Grubb1,2. On immunoelectrophoresis with different rabbit antisera against human whole serum (supplied by Behringwerke, W. Germany) the γ-globulin preparations showed the character of 7S γ-globulin. No β2A or β2M was present.

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  1. 1

    Grubb, R., Acta Path. Microbiol. Scand., 39, 195 (1956).

  2. 2

    Grubb, R., and Laurell, A.-B., Acta Path. Microbiol. Scand., 39, 390 (1956).

  3. 3

    Hjertén, S., Biochim. Biophys. Acta, 31, 216 (1959).

  4. 4

    Heremans, J., Les globulines sériques du systéme gamma, 119 (Editions Arscia, S.A., Bruxelles, 1960).

  5. 5

    Kunkel, H. G., Müller-Eberhard, H. J., Fudenberg, H. H., and Tomasi, T. B., J. Clin. Invest., 40, 117 (1961).

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  1. Department of Clinical Chemistry, University of Uppsala



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