Letter | Published:

Permeability of the Synovial Membrane to Glycoproteins

Nature volume 192, page 1192 (23 December 1961) | Download Citation

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Abstract

ELECTROPHORETIC investigations have indicated differences in glycoprotein pattern between serum and synovial fluid1–3. The most marked difference is that the relative amount of α2-glycoproteins is considerably less in synovial fluid than in serum. It was recently demonstrated4 that the low α2-content of rheumatoid arthritic synovial fluid is mainly due to the low concentration of haptoglobin. The synovial fluid–serum ratio for this glycoprotein was significantly lower than for albumin or γ-globulin. The concentration of the small-molecular glycoprotein orosomucoid was, on the other hand, that expected from the total protein content, indicating a varied permeability of the blood-synovial fluid barrier to glycoproteins.

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Author information

Affiliations

  1. Central Clinical Laboratory and Medical Department III, Södersjukhuset (South Hospital), Stockholm.

    • LARS SUNDBLAD
    • , ERIC JONSSON
    •  & ERIK NETTELBLADT

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DOI

https://doi.org/10.1038/1921192a0

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